TB500 10MG

🔬 Product Code: TB-10MG

🧪 Specification: 10mg Lyophilized Powder

🧬 Purity: ≥99% Verified via HPLC / MS

⚠️ Application: For In-Vitro and Preclinical Laboratory Research Only. Not for human or veterinary use.

Product Overview

TB-500 is a synthetic peptide that represents the active, short-chain fragment of the naturally occurring 43-amino acid protein Thymosin Beta-4 ($\text{T}\beta\text{4}$). Structurally, it isolates the exact functional sequence responsible for the parent protein’s profound cellular migration and wound-healing properties.

In molecular biology and regenerative medicine research, TB-500 is heavily investigated for its role as a major actin-sequestering molecule. By binding to G-actin (monomeric actin), it directly regulates actin polymerization—the cellular machinery required for cell movement and structural organization.

Because of its low molecular weight, TB-500 features high systemic mobility across tissue barriers. In preclinical models, it diffuses rapidly to targeted zones of physical trauma to promote angiogenesis (new blood vessel sprouts), upregulate matrix metalloproteinases, and accelerate the migration of endothelial cells and keratinocytes to fast-track soft tissue repair.

Key Research Applications

• Actin Polymerization & Cell Mobility: Mapping out the structural mechanics of cell migration, tissue remodeling, and cellular movement during physical injury assays.

• Angiogenesis and Vascular Growth: Investigating the upregulation of vascular endothelial factors to observe how the peptide builds stable, microvascular blood supply networks in damaged tissue.

• Soft Tissue & Connective Repair: Evaluating the rates of collagen deposition, fiber alignment, and overall functional recovery in animal models of tendon, ligament, and muscle tears.

Uncompromising Quality Control

Every batch of TB-500 distributed by Onyx Research undergoes independent, third-party analytical testing to guarantee reproducible experimental results.

• High-Performance Liquid Chromatography (HPLC): Confirms an exact purity profile exceeding 99%.

• Mass Spectrometry (MS): Verifies correct sequence identity and precise molecular weight alignment ($4963.4\text{ Da}$).

• Lyophilization Technology: Vacuum-sealed to ensure optimal structural stability during transport and storage phases.

Handling & Storage Guidelines

• Form: Lyophilized (freeze-dried) white crystalline powder.

• Reconstitution: For laboratory testing, reconstitute using sterile bacteriostatic water. Guide the fluid gently down the internal glass wall of the vial and swirl slowly. Avoid any aggressive shaking or vortexing to prevent structural shearing of the peptide.

• Storage (Lyophilized): Stable at room temperature for up to 4 weeks during transit. Store long-term at $-20^\circ\text{C}$ to preserve peptide integrity for up to 24 months.

• Storage (Reconstituted): Once in solution, store under refrigeration at $2^\circ\text{C}$ to $8^\circ\text{C}$ and utilize within 10 to 14 days for optimal experimental consistency.

Laboratory Safety Disclaimer: This compound is supplied exclusively to qualified professionals, academic institutions, and commercial laboratories engaged in scientific innovation. Onyx Research explicitly prohibits the administration of this material to humans or animals. All handling must conform to strict laboratory safety standards, including the use of proper personal protective equipment (PPE).