Tesamorelin 10mg

🔬 Product Code: TES-10MG

🧪 Specification: 10mg Lyophilized Powder

🧬 Purity: ≥99% Verified via HPLC / MS

⚠️ Application: For In-Vitro and Preclinical Laboratory Research Only. Not for human or veterinary use.

Tesamorelin 10mg Product Overview

Tesamorelin (research code TH9507) is a synthetic analog of endogenous Growth Hormone-Releasing Hormone (GHRH). Structurally, it consists of the complete 44-amino acid sequence of human GHRH with a critical modification: a trans-3-hexenoic acid group attached to the N-terminal tyrosine residue. This deliberate structural stabilization significantly increases its resistance to enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4), vastly extending its biological half-life and experimental potency compared to native GHRH.

In neuroendocrine and metabolic research, Tesamorelin functions as a highly specific agonist of GHRH receptors located on somatotroph cells in the anterior pituitary gland. Its primary mechanism of action involves triggering the synthesis and pulsatile release of endogenous Growth Hormone (GH), which subsequently elevates circulating levels of Insulin-like Growth Factor 1 (IGF-1).

Crucially, Tesamorelin is widely investigated for its tissue-specific metabolic effects. In preclinical models, the resulting physiological GH increase acts directly on adipocytes to upregulate lipolysis (the breakdown of stored fat) and significantly reduce visceral adipose tissue (VAT) accumulation, without causing detrimental disruptions to baseline glucose homeostasis.

Key Research Applications

• Visceral Adiposity & Lipodystrophy Modeling: Investigating the precise cellular pathways governing the selective reduction of deep visceral fat deposits versus subcutaneous fat layers.

• Pituitary GHRH Receptor Kinetics: Mapping the downstream signaling cascades, cAMP pathway activation, and pulsatile secretion rhythms of growth hormone under sustained, stabilized GHRH receptor agonism.

• Metabolic Syndrome and Homeostasis: Analyzing the concurrent adjustments in body composition, lipid profiles, and insulin sensitivity markers in animal metabolic assays.

Uncompromising Quality Control

Every batch of Tesamorelin distributed by Onyx Research undergoes independent, third-party analytical testing to guarantee reproducible experimental results.

• High-Performance Liquid Chromatography (HPLC): Confirms an exact purity profile exceeding 99%.

• Mass Spectrometry (MS): Verifies correct sequence identity and precise molecular mass ($5135.9\text{ Da}$) ensuring zero structural degradation.

• Lyophilization Technology: Vacuum-sealed in clinical-grade glass vials to guarantee optimal structural stability across transit and storage environments.

Handling & Storage Guidelines

• Form: Lyophilized (freeze-dried) white crystalline powder.

• Reconstitution: Reconstitute using sterile bacteriostatic water. Introduce the liquid gently down the internal glass wall of the vial and swirl slowly. Do not shake, vibrate, or agitate aggressively to prevent protein shearing.

• Storage (Lyophilized): Stable at room temperature for up to 4 weeks during transit. Store long-term at $-20^\circ\text{C}$ to preserve peptide integrity for up to 24 months.

• Storage (Reconstituted): Once in solution, store under refrigeration at $2^\circ\text{C}$ to $8^\circ\text{C}$ and utilize within 10 to 14 days for optimal experimental consistency.

Laboratory Safety Disclaimer: This compound is supplied exclusively to qualified professionals, academic institutions, and commercial laboratories engaged in scientific innovation. Onyx Research explicitly prohibits the administration of this material to humans or animals. All handling must conform to strict laboratory safety standards, including the use of proper personal protective equipment (PPE).