KISSPEPTIN 10MG

🔬 Product Code: KIS-10MG

🧪 Specification: 10mg Lyophilized Powder

🧬 Purity: ≥99% Verified via HPLC / MS

⚠️ Application: For In-Vitro and Preclinical Laboratory Research Only. Not for human or veterinary use.

Product Overview

Kisspeptin-10 is a highly potent, truncated synthetic peptide fragment containing the core 10-amino acid sequence derived from the C-terminus of the full-length human kisspeptin protein (Kisspeptin-54, encoded by the KISS1 gene). Structurally, it represents the minimum active sequence required to display full biological efficacy at its target site.

In neuroendocrine and reproductive physiology research, Kisspeptin-10 functions as the primary, high-affinity endogenous agonist for the G-protein-coupled receptor 54 (GPR54), also known as the Kisspeptin Receptor (KISS1R). Located prominently on hypothalamic neurons, the activation of this receptor by Kisspeptin acts as the foundational, upstream “master switch” that triggers the pulsatile release of Gonadotropin-Releasing Hormone (GnRH).

Once GnRH release is initiated, it flows down to the anterior pituitary gland to stimulate the secretion of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH), ultimately regulating the downstream synthesis of sex steroids (testosterone and estrogen). Because it targets the topmost tier of the hypothalamic-pituitary-gonadal (HPG) axis, Kisspeptin-10 is an indispensable tool for mapping puberty onset, fertility cascades, and central endocrine regulation.

Key Research Applications

• Upstream HPG Axis Regulation: Investigating the precise neuronal feedback loops and signaling mechanisms that control pulsatile GnRH release.

• Fertility & Reproductive Modeling: Studying the impact of central receptor activation on egg maturation, ovulation triggers, and spermatogenesis acceleration in animal subjects.

• Oncology & Metastasis Suppression: Evaluating the secondary, historical role of KISS1 signaling cascades as a major metastasis suppressor in specific malignant cell lines.

Uncompromising Quality Control

Every batch of Kisspeptin-10 distributed by Onyx Research undergoes independent, third-party analytical testing to guarantee reproducible experimental results.

• High-Performance Liquid Chromatography (HPLC): Confirms an exact purity profile exceeding 99%.

• Mass Spectrometry (MS): Verifies correct sequence identity (Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2) and precise molecular weight ($1302.4\text{ Da}$).

• Lyophilization Technology: Vacuum-sealed to ensure optimal structural stability during transport and storage.

Handling & Storage Guidelines

• Form: Lyophilized (freeze-dried) white crystalline powder.

• Reconstitution: For laboratory testing, reconstitute using sterile bacteriostatic water. Introduce the liquid gently down the internal glass wall of the vial and swirl slowly. Avoid any aggressive shaking or vortexing to prevent structural shearing of the peptide.

• Storage (Lyophilized): Stable at room temperature for up to 4 weeks during transit. Store long-term at $-20^\circ\text{C}$ to preserve peptide integrity for up to 24 months.

• Storage (Reconstituted): Once in solution, store under refrigeration at $2^\circ\text{C}$ to $8^\circ\text{C}$ and utilize within 10 to 14 days for optimal experimental consistency.

Laboratory Safety Disclaimer: This compound is supplied exclusively to qualified professionals, academic institutions, and commercial laboratories engaged in scientific innovation. Onyx Research explicitly prohibits the administration of this material to humans or animals. All handling must conform to strict laboratory safety standards, including the use of proper personal protective equipment (PPE).