SEMAX/SELANK NASAL SPRAY

🔬 Product Code: NS-SEM-SEL

🧪 Specification: Co-Formulated Nasal Spray (Multi-Neuropeptide Matrix)

🧬 Purity: ≥99% Combined API Purity Verified via HPLC / MS

⚠️ Application: For Preclinical Behavioral and Neurobiological Laboratory Research Only. Not for human or veterinary use.

Product Overview

The Semax / Selank Nasal Spray is an innovative, dual-action neuropeptide configuration engineered to study the simultaneous pathways of neuroprotection, cognitive enhancement, and anxiolytic (anxiety-reducing) modulation. This specialized liquid solution blends two of the most heavily researched synthetic ACTH and tuftsin derivatives into a precise nasal delivery matrix, allowing for the observation of overlapping central nervous system (CNS) cascades:

• Semax: A synthetic heptapeptide derived from the N-terminal ACTH(4-10) fragment, stabilized with a Pro-Gly-Pro sequence at its C-terminus. In neurological research, Semax acts as a potent driver of cognitive processing, rapidly upregulating Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF) within the hippocampus and frontal cortex.

• Selank: A synthetic heptapeptide analog of the endogenous immunomodulatory peptide tuftsin, similarly stabilized with a Pro-Gly-Pro C-terminus. Selank functions through an independent pathway, modulating the activity of Gamma-Aminobutyric Acid (GABA) by altering expression profiles of GABA-A receptor subunits and slowing down the enzymatic degradation of enkephalins to deliver distinct anti-stress effects.

By combining these distinct mechanisms in an intranasal administration profile, this matrix allows researchers to study a balanced neurological response. Semax actively promotes synaptic plasticity and alertness, while Selank mitigates stress and stabilizes behavioral anxiety markers—completely bypassing the blood-brain barrier hurdles associated with traditional systemic administration methods.

Key Research Applications

• Cognitive-Anxiolytic Crosstalk: Investigating how the concurrent upregulation of neurotrophins (BDNF) and optimization of inhibitory neurotransmission (GABA) affect learning and task adaptation in animal models under stress.

• Intranasal Delivery Dynamics: Evaluating the absorption rates, pharmacokinetic profiles, and direct-to-brain pathway efficiency of co-formulated neuropeptides.

• Neurological Stress Mitigation: Modeling cellular and behavioral responses to environmental or physiological stress when treated simultaneously with neuroprotective and stress-buffering agents.

Uncompromising Quality Control

Every intranasal solution distributed by Onyx Research undergoes separate and combined independent, third-party analytical verification to guarantee absolute data integrity.

• High-Performance Liquid Chromatography (HPLC): Confirms absolute baseline purity (guaranteed $\ge 99\%$) for both independent Active Pharmaceutical Ingredients (APIs).

• Mass Spectrometry (MS): Verifies correct sequence identities and precise molecular weights ($812.9\text{ Da}$ for Semax; $751.9\text{ Da}$ for Selank).

• Precise Metered Dosing: Formulated with a medical-grade, calibrated intranasal actuator to ensure highly reproducible dosing volumes per spray during preclinical protocols.

Handling & Storage Guidelines

• Form: Pre-dissolved, metered intranasal solution.

• Storage (Long-Term): Store under constant refrigeration at $2^\circ\text{C}$ to $8^\circ\text{C}$ to prevent peptide degradation and preserve structural integrity. Do not freeze the liquid solution.

• Stability: Protect from direct UV light, excessive heat, and rough agitation. Under proper refrigerated conditions, the solution remains highly stable for up to 6 months.

Laboratory Safety Disclaimer: This compound solution is supplied exclusively to qualified professionals, academic institutions, and commercial laboratories engaged in scientific innovation. Onyx Research explicitly prohibits the administration of this material to humans or animals. All handling must conform to strict laboratory safety standards, including the use of proper personal protective equipment (PPE).