Cagrilintide 10mg

🔬 Product Code: CAG-10MG

🧪 Specification: 10mg Lyophilized Powder

🧬 Purity: ≥99% Verified via HPLC / MS

⚠️ Application: For In-Vitro and Preclinical Laboratory Research Only. Not for human or veterinary use.

Product Overview

Cagrilintide 10mg is an investigational, long-acting, acylated amylin analogue designed to study advanced metabolic regulation and satiety pathways. Structurally, it functions as a non-selective agonist of both the amylin receptors (AMYRs) and the calcitonin G-protein-coupled receptors (CTRs).

In neuroendocrine and preclinical research, amylin is a peptide hormone naturally co-secreted with insulin by pancreatic beta-cells to manage postprandial (post-meal) glucose homeostasis. Cagrilintide is engineered with a specific fatty acid side-chain modification (acylation) that allows it to bind reversibly to albumin, drastically extending its experimental half-life to enable once-weekly testing windows in animal models. It represents a major area of research focus regarding dual-receptor activation for weight management, independent of traditional incretin (GLP-1/GIP) pathways.

Key Research Applications

• Dual Amylin & Calcitonin Receptor Agonism (DACRA): Investigating how simultaneous activation of AMYRs and CTRs in the brainstem coordinates homeostatic and hedonic (reward-based) eating behaviors.

• Synergistic Incretin Co-Administration: Serving as a primary variable in dual-therapy models combined with GLP-1 receptor agonists (such as Semaglutide) to study non-redundant, multi-pathway metabolic outcomes.

• Gastric Motility & Satiety Signaling: Analyzing the rate of delayed gastric emptying and postprandial glucagon suppression in cell cultures and animal tissue models.

Uncompromising Quality Control

Every batch of Cagrilintide distributed by Onyx Research undergoes independent, third-party analytical verification to protect the accuracy of your assays.

• High-Performance Liquid Chromatography (HPLC): Guarantees a strict purity profile of $\ge 99\%$.

• Mass Spectrometry (MS): Confirms absolute identity and correct molecular weight ($4409.01\text{ Da}$).

• Lyophilization Technology: Vacuum-sealed to ensure optimal peptide stability during transport and storage.

Handling & Storage Guidelines

• Form: Lyophilized (freeze-dried) white crystalline powder.

• Reconstitution: For laboratory testing, reconstitute using sterile bacteriostatic water. Due to its acylated structure, ultra-sonic assistance or gentle swirling may be used; avoid aggressive shaking to prevent structural degradation.

• Storage (Lyophilized): Stable at room temperature for up to 4 weeks during transit. Store long-term at $-20^\circ\text{C}$ to preserve peptide integrity for up to 24 months.

• Storage (Reconstituted): Once in solution, store under refrigeration at $2^\circ\text{C}$ to $8^\circ\text{C}$ and utilize within 10 to 14 days for optimal experimental consistency.

Laboratory Safety Disclaimer: This compound is supplied exclusively to qualified professionals, academic institutions, and commercial laboratories engaged in scientific innovation. Onyx Research explicitly prohibits the administration of this material to humans or animals. All handling must conform to strict laboratory safety standards, including the use of proper personal protective equipment (PPE).