Enclomiphene

🔬 Product Code: ENC-CAP-50

🧪 Specification: Research-Grade Oral Capsules

🧬 Purity: ≥99% Pure API Verified via HPLC / MS

⚠️ Application: For Preclinical Laboratory Research Use Only. Not for human or veterinary consumption.

Product Overview

Enclomiphene is a non-steroidal selective estrogen receptor modulator (SERM). It is the purified chemical ($\text{E}$)-isomer of clomiphene citrate, isolated entirely from its counterpart, zuclomiphene.

In endocrine and reproductive research models, Enclomiphene functions as a potent, clean estrogen receptor antagonist at the level of the hypothalamus and pituitary gland. By binding to and blocking these central receptors, it prevents the negative feedback loop normally exerted by circulating estrogens.

Unlike the mixed isomer clomiphene (which contains the estrogenic ($\text{Z}$)-isomer that persists in tissue for months), pure Enclomiphene acts as a highly selective antagonist. This selective blocking prompts the pituitary gland to upregulate the secretion of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). In animal models, this targeted gonadotropin rise directly stimulates the testicular Leydig cells to increase endogenous testosterone production, while simultaneously promoting spermatogenesis via Sertoli cell activation.

Key Research Applications

• Hypogonadal Modeling & Recovery: Investigating mechanisms to restore or elevate baseline endogenous testosterone production without causing testicular atrophy or introducing exogenous hormones.

• Gonadotropin Cascade Isolation: Studying the specific upstream signaling pathways of LH and FSH synthesis when freed from central estrogenic suppression.

• Isomer-Specific Comparative Assays: Evaluating the distinct biochemical divergence, half-life metrics, and safety profiles between pure ($\text{E}$)-enclomiphene and mixed-isomer clomiphene solutions.

Uncompromising Quality Control

Every batch of Enclomiphene distributed by Onyx Research undergoes independent, third-party analytical testing to guarantee reproducible experimental results.

• High-Performance Liquid Chromatography (HPLC): Confirms an exact purity profile of the Active Pharmaceutical Ingredient (API) exceeding 99%.

• Mass Spectrometry (MS): Verifies precise chemical identity and ensures complete isolation from the zuclomiphene isomer.

• Accurate Dosing: Formulated in uniformly measured research capsules for exact, highly reproducible administration in oral-delivery protocols.

Handling & Storage Guidelines

• Form: Solid oral research capsules.

• Storage (Long-Term): Store in a cool, dry place ($15^\circ\text{C}$ to $25^\circ\text{C}$) inside the original container. Keep tightly sealed and shielded from direct UV light, moisture, and excessive heat.

• Stability: Chemically stable at room temperature for up to 24 months when stored under optimal laboratory conditions.

Laboratory Safety Disclaimer: This compound is supplied exclusively to qualified professionals, academic institutions, and commercial laboratories engaged in scientific innovation. Onyx Research explicitly prohibits the administration of this material to humans or animals. All handling must conform to strict laboratory safety standards, including the use of proper personal protective equipment (PPE).