MOTS-C 10MG

🔬 Product Code: MOTS-10MG

🧪 Specification: 10mg Lyophilized Powder

🧬 Purity: ≥99% Verified via HPLC / MS

⚠️ Application: For In-Vitro and Preclinical Laboratory Research Only. Not for human or veterinary use.

Product Overview

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a cutting-edge, naturally occurring mitochondrial-derived peptide (MDP) consisting of 16 amino acids. It represents a major breakthrough in cellular biology, demonstrating that mitochondria possess their own distinct retrograde signaling mechanisms to communicate with and regulate the nuclear genome.

In metabolic and longevity research, MOTS-c acts primarily as an autonomous endocrine factor that targets skeletal muscle and systemic tissues. Its primary mechanism centers on the activation of the AMP-activated protein kinase (AMPK) pathway and the upregulation of glucose transporter 4 (GLUT4) expression.

By stimulating these crucial energetic pathways, MOTS-c increases intracellular $\text{NAD}^+$ levels, enhances cellular glucose uptake, and restores insulin sensitivity in metabolic animal models. Furthermore, it actively intercepts and suppresses the metabolic stress response, making it a pivotal target for studying cellular resilience, systemic energy expenditure, and age-related metabolic decline.

Key Research Applications

• Mitochondrial Signaling & Nuclear Crosstalk: Investigating how MDPs translocate to the cell nucleus during metabolic stress to transactivate specific adaptive genes.

• Insulin Sensitivity & Metabolic Profiling: Mapping the peptide’s ability to restore normal glucose clearance and lipid homeostasis in models of induced insulin resistance.

• Physical Capacity & Longevity Assays: Evaluating changes in cellular energy production, oxygen consumption rate (OCR), and overall physical performance markers in aging animal subjects.

Uncompromising Quality Control

Every batch of MOTS-c distributed by Onyx Research undergoes independent, third-party analytical verification to protect the accuracy of your assays.

• High-Performance Liquid Chromatography (HPLC): Guarantees a strict baseline purity profile of $\ge 99\%$.

• Mass Spectrometry (MS): Confirms absolute molecular mass and exact amino acid sequence alignment (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg).

• Lyophilization Technology: Vacuum-sealed to ensure optimal structural stability during transport and storage phases.

Handling & Storage Guidelines

• Form: Lyophilized (freeze-dried) white crystalline powder.

• Reconstitution: Reconstitute with sterile bacteriostatic water. Introduce the diluent gently down the inner glass wall of the vial and swirl slowly. Do not shake or vortex aggressively to prevent protein shearing.

• Storage (Lyophilized): Stable at room temperature for up to 4 weeks during transit. Store long-term at $-20^\circ\text{C}$ to preserve peptide integrity for up to 24 months.

• Storage (Reconstituted): Once in solution, store under refrigeration at $2^\circ\text{C}$ to $8^\circ\text{C}$ and utilize within 10 to 14 days for optimal experimental consistency.

Laboratory Safety Disclaimer: This compound is supplied exclusively to qualified professionals, academic institutions, and commercial laboratories engaged in scientific innovation. Onyx Research explicitly prohibits the administration of this material to humans or animals. All handling must conform to strict laboratory safety standards, including the use of proper personal protective equipment (PPE).