SEMAX

🔬 Product Code: SEM-10MG

🧪 Specification: 10mg Lyophilized Powder

🧬 Purity: ≥99% Verified via HPLC / MS

⚠️ Application: For In-Vitro and Preclinical Laboratory Research Only. Not for human or veterinary use.

Product Overview

Semax is a synthetic heptapeptide derived from the N-terminal fragment of Adrenocorticotropic Hormone (ACTH), specifically the ACTH(4-10) sequence. It features a unique structural modification: the addition of a Pro-Gly-Pro tripeptide sequence at its C-terminus (forming Met-Glu-His-Phe-Pro-Gly-Pro). This stabilization completely protects the peptide from rapid enzymatic degradation in a biological matrix, extending its half-life and allowing for stable experimental assessment.

In neurobiology and behavioral neuroscience research, Semax is classified as a highly potent neuropeptide with distinct nootropic and neuroprotective properties. Crucially, it functions completely independently of the systemic hormonal cascades typically associated with full-length ACTH.

Its primary mechanism of action relies on the rapid upregulation of Brain-Derived Neurotrophic Factor (BDNF) and its corresponding high-affinity receptor, Tyrosine Kinase B (TrkB), within the hippocampus and frontal cortex models. By boosting neurotrophin expression, Semax triggers downstream signaling pathways that promote synaptic plasticity, support cellular survival, and protect neurons from oxidative stress and hypoxic injury.

Key Research Applications

• Neurogenesis & Synaptic Plasticity: Mapping out how prolonged neuropeptide exposure influences dendritic branching, long-term potentiation (LTP), and cognitive processing markers in animal brains.

• Ischemic Stroke & Hypoxia Modeling: Investigating the cellular survival rates and neuroprotective responses of cortical neurons subjected to oxygen-glucose deprivation.

• Dopaminergic & Serotonergic Modulation: Studying the regulatory crosstalk between Semax and the monoaminergic neurotransmitter systems during states of heavy neurological stress or behavioral modeling.

Uncompromising Quality Control

Every batch of Semax distributed by Onyx Research undergoes independent, third-party analytical testing to guarantee reproducible experimental results.

• High-Performance Liquid Chromatography (HPLC): Confirms an exact purity profile exceeding 99%.

• Mass Spectrometry (MS): Verifies correct sequence composition and precise molecular weight ($812.9\text{ Da}$).

• Lyophilization Technology: Vacuum-sealed to ensure optimal structural stability during transport and storage phases.

Handling & Storage Guidelines

• Form: Lyophilized (freeze-dried) white crystalline powder.

• Reconstitution: For laboratory testing, reconstitute using sterile bacteriostatic water or sterile physiological saline. Guide the fluid gently down the internal glass wall of the vial and swirl slowly. Avoid vigorous shaking or vortexing to prevent peptide shearing.

• Storage (Lyophilized): Stable at room temperature for up to 4 weeks during transit. Store long-term at $-20^\circ\text{C}$ to preserve peptide integrity for up to 24 months.

• Storage (Reconstituted): Once in solution, store under refrigeration at $2^\circ\text{C}$ to $8^\circ\text{C}$ and utilize within 10 to 14 days for optimal experimental consistency.

Laboratory Safety Disclaimer: This compound is supplied exclusively to qualified professionals, academic institutions, and commercial laboratories engaged in scientific innovation. Onyx Research explicitly prohibits the administration of this material to humans or animals. All handling must conform to strict laboratory safety standards, including the use of proper personal protective equipment (PPE).