CJC W Dac 5mg

🔬 Product Code: CJC-WDAC-5MG

🧪 Specification: 5mg Lyophilized Powder

🧬 Purity: ≥99% Verified via HPLC / MS

⚠️ Application: For In-Vitro and Preclinical Laboratory Research Only. Not for human or veterinary use.

Product Overview

CJC-1295 With DAC (Drug Affinity Complex) is a synthetic 30-amino acid analog of Growth Hormone-Releasing Hormone ($\text{GHRH}$). It is a modified version of the core $\text{GHRH}$ fragment (Modified GRF 1-29) featuring a crucial addition: a non-reactive maleimidooproprionic acid linker at the C-terminus.

In preclinical and physiological research, the integration of this proprietary Drug Affinity Complex (DAC) dramatically alters the pharmacokinetic profile of the peptide. Once introduced into a fluid matrix, the DAC linker covalently binds specifically to endogenous serum albumin. This structural anchoring shields the compound from rapid enzymatic degradation and renal clearance.

While the standard version (CJC-1295 No DAC) has a short half-life measured in minutes, CJC-1295 With DAC exhibits an extended experimental half-life spanning 5 to 8 days. Consequently, instead of mimicking the natural, rapid physiological spikes of growth hormone, this compound provides a prolonged, continuous stimulation of pituitary somatotrophs, leading to elevated baseline levels of growth hormone ($\text{GH}$) and Insulin-like Growth Factor 1 ($\text{IGF-1}$) in animal models.

Key Research Applications

• Extended Pharmacokinetic Modeling: Investigating the cellular impact of continuous, non-pulsatile $\text{GHRH}$ receptor saturation over long test windows.

• Systemic IGF-1 Upregulation Studies: Evaluating long-term changes in nitrogen retention, cellular protein synthesis, and metabolic homeostasis under steady-state growth hormone levels.

• Comparative Secretagogue Research: Serving as the primary long-acting variable when comparing pulsatile secretagogues (like CJC-1295 No DAC) against sustained-release analogs.

Uncompromising Quality Control

Every batch of CJC-1295 With DAC distributed by Onyx Research undergoes independent, third-party analytical testing to guarantee reproducible experimental results.

• High-Performance Liquid Chromatography (HPLC): Confirms an exact purity profile exceeding 99%.

• Mass Spectrometry (MS): Verifies correct sequence identity and precise molecular weight ($3647.2\text{ Da}$ for the base peptide structure).

• Lyophilization Technology: Vacuum-sealed to ensure optimal structural stability during transport and storage.

Handling & Storage Guidelines

• Form: Lyophilized (freeze-dried) white crystalline powder.

• Reconstitution: For laboratory testing, reconstitute using sterile bacteriostatic water. Guide the solution gently down the glass wall of the vial. Do not shake or agitate aggressively to prevent peptide shear.

• Storage (Lyophilized): Stable at room temperature for up to 4 weeks during transit. Store long-term at −20∘C to preserve peptide integrity for up to 24 months.

• Storage (Reconstituted): Once in solution, store under refrigeration at 2∘C to 8∘C and utilize within 10 to 14 days for optimal experimental consistency.

Laboratory Safety Disclaimer: This compound is supplied exclusively to qualified professionals, academic institutions, and commercial laboratories engaged in scientific innovation. Onyx Research explicitly prohibits the administration of this material to humans or animals. All handling must conform to strict laboratory safety standards, including the use of proper personal protective equipment (PPE).